ABOLOGIX is developing best-in-class monoclonal antibodies by blocking the Junction Adhesion Molecule JAM-C and the extracellular matrix-related protein Olfactomedin-like protein 3 (Olfml3).
Blocking JAM-C is a novel approach for the treatment of non-Hodgkin´s lymphoma.
Olfml3 is a proangiogenic factor in the tumor microenvironment, being released by endothelial cells and pericytes. Blocking Olfml3 can lead to a new generation of angiogenic inhibitors.
The company is based in Geneva (Switzerland) and it is a spin-out from the laboratories of Profs. Beat Imhof and Thomas Matthes at the Université de Genève and the Hôpitaux Universitaires de Genève.